Efficacy and safety of pemafibrate versus bezafibrate in coronary artery disease patients receiving statin treatment: a randomized, open-label, cross-over study
نویسندگان
چکیده
Abstract Background Fibrates activate peroxisome proliferator-activated receptor (PPAR)-α which is associated with lipid metabolism. Bezafibrate a non-selective PPAR-α agonist, whereas pemafibrate has been developed as higher selective agonist. Objective The efficacy and safety of for 24-week in patients dyslipidemia was examined comparison bezafibrate. Methods Sixty hypertriglyceridemia (fasting triglyceride (TG) level ≥150 mg/dL) were treated 0.2 mg/day or bezafibrate 400 randomized cross-over study. Percent change from baseline TG levels the primary endpoint, that HDL-C apolipoprotein A-I (Apo A-I) secondary endpoints. Results A significantly greater reduction percent observed than (−46.1% vs. −34.7%, p<0.001). There no significant difference between (18.4% 14.0%, p=0.067), Apo (9.2% 5.7%, p=0.018). Pemafibrate decreased alanine aminotransferase (ALT) gamma-glutamyltransferase (γ-GT) levels, showed (ALT: −21.9% −10.6%, p=0.048; γ-GT: −43.5% −33.1%, p=0.025). Creatinine increased both treatments (both p<0.001), however, creatinine smaller (5.72% 15.5%, frequency adverse event (AE) serious AE two treatments, but elevation (≥0.5 mg/d and/or 25%) (16/60 3/60, p=0.004). Conclusion As compared bezafibrate, more effective to reduce elevate it safer terms liver renal function. Funding Acknowledgement Type funding sources: None.
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ژورنال
عنوان ژورنال: European Heart Journal
سال: 2022
ISSN: ['2634-3916']
DOI: https://doi.org/10.1093/eurheartj/ehac544.2665